In this video, Reena Jadhav interviews author James Clement and discusses the metabolic benefits of intermittent fasting. Specifically, they analyze some of the concepts present in Clement’s book, “The Switch,” which discusses the importance of the metabolic switch mTOR. It also happens to be our next book club book!
Who is James Clement?
- He is an entrepreneur-turned-research scientist
- Focused on lifespan and longevity
- Wants to find the next molecule to help us live longer and disease-free
- Famous for one of his supercentenarian research studies
Why Did He Write the Book?
- Clement is focused on the biology of aging and how we can extend our lifespan
- One of the easiest ways to achieve longevity is calorie restriction, which can be achieved through intermittent fasting
- He believes learning about mTOR and its triggers is crucial to maintaining good health
The Bird’s Eye View:
- There is a metabolic switch known as mTOR
- Discovered in the 1990s
- Metabolism switches between an anabolic (growing and building) and a catabolic (breaking down) state
- This switch can be linked to nearly every disability we associated with old age, as well as every life-extending practice we use today
- Found due to the discovery of rapamycin, an antimicrobial with a ton of interesting properties
- Slowing/inhibiting self-growth
- Can be used in cancer cells
- Slowing/inhibiting self-growth
- The target of this drug is mTOR (which stands for mechanistic target of rapamycin)
- In mammals, is a complex set of pathways and proteins
A More In-Depth Look:
- Autophagy is a survival mechanism that originally evolved in bacteria
- Used to “hunker down” during famine and use resources from their own cells for energy (such as misfolded proteins or broken mitochondria)
- Autophagy and catabolism are upregulated (turned on) when we are in a nutrient-deprived state
- Nutrient sensors within this complex are responsible for telling mTOR if it should turn on
- These sensors include insulin and oxygen
Implications of mTOR:
- Food pyramid built before the discovery of mTOR, our relatively new understanding of this pathway might impact our views of diet and nutrition
- Currently over a thousand clinical trials on the use of rapamycin for Crohn’s disease
Learn More About the Process Of Autophagy:
And, if you are interested in discussing more about “The Switch” and other fascinating books, please feel free to join our book club!
How can you lose dramatic weight, ease chronic conditions, and stay healthier longer? Flip the switch on your metabolism with intermittent fasting, protein cycling, and keto!
Within each of us is an ancient mechanism that eliminates toxic materials, initiates fat burning, and protects cells from becoming dysfunctional—or turning cancerous. It’s called autophagy, and when it’s turned on, the complex operation not only can slow down the aging process, it can optimize biological function as a whole, helping to stave off all manner of diseases and affording us the healthy life spans we never thought possible. It’s the body’s ultimate switch to life.
So how can we positively activate this switch? How frequently should we fast and for how long? Which foods dial-up autophagy or, conversely, turn it down? How much exercise and what types are recommended? What’s the sweet spot between intermittent fasting, protein cycling, and ketogenic eating?
Backed by a wealth of scientific data and featuring a gallery of guidelines to follow for lasting results, The Switch decodes the science of autophagy and teaches you how to control it and maximize its profound impact.